Carlos A M Fraga Selected Research

phenylpiperazine

1/2019	Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D2 Receptor.
1/2013	New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia.
5/2010	Design of new dopamine D2 receptor ligands: biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581.
3/2010	Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.
3/2008	Serotonergic neurotransmission mediates hypothermia induced by the N-phenylpiperazine antipsychotic prototypes LASSBio-579 and LASSBio-581.

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Carlos A M Fraga Research Topics

Disease

9	Schizophrenia (Dementia Praecox) 01/2019 - 03/2008
7	Neoplasms (Cancer) 01/2021 - 09/2008
5	Inflammation (Inflammations) 12/2019 - 03/2005
3	Chronic Pain 01/2014 - 11/2009
3	Hyperalgesia 01/2014 - 01/2009
3	Edema (Dropsy) 04/2011 - 01/2009
2	Chagas Disease (American Trypanosomiasis) 07/2020 - 01/2020
2	Neurobehavioral Manifestations 01/2017 - 01/2016
2	Pulmonary Hypertension 05/2014 - 07/2013
2	Neuralgia (Stump Neuralgia) 01/2014 - 07/2013
2	Amnesia (Dissociative Amnesia) 02/2008 - 07/2005
1	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2020
1	Colorectal Neoplasms (Colorectal Cancer) 12/2019
1	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular) 05/2019
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 05/2019
1	Chronic Disease (Chronic Diseases) 01/2018
1	Catatonia 01/2017
1	Granuloma 01/2017
1	Silicosis 01/2017
1	Lung Injury 01/2017
1	Lung Diseases (Lung Disease) 01/2017
1	Cocaine-Related Disorders (Cocaine Addiction) 01/2016
1	Erectile Dysfunction 05/2015
1	Hyperthermia 01/2014
1	Peripheral Nerve Injuries 07/2013
1	Pain (Aches) 07/2013
1	Catalepsy 01/2013
1	Neglected Diseases 11/2011
1	Plague (Bubonic Plague) 10/2011
1	Myocardial Infarction 11/2010
1	Heart Failure 11/2010
1	Cardiomegaly (Heart Hypertrophy) 11/2010
1	Cognitive Dysfunction 11/2009

Drug/Important Bio-Agent (IBA)

8	Pharmaceutical PreparationsIBA 07/2020 - 01/2009
5	phenylpiperazineIBA 01/2019 - 03/2008
5	LASSBio-579IBA 01/2019 - 03/2008
3	Histone Deacetylases (Histone Deacetylase)IBA 01/2021 - 01/2020
3	CarrageenanIBA 01/2014 - 01/2009
2	Histone Deacetylase InhibitorsIBA 01/2021 - 11/2020
2	Antipsychotic Agents (Antipsychotics)IBA 01/2019 - 01/2013
2	LigandsIBA 01/2019 - 01/2013
2	EnzymesIBA 01/2016 - 01/2009
2	Apomorphine FDA Link 01/2016 - 01/2013
2	Adenosine A2A Receptor (Adenosine A2A Receptors)IBA 05/2015 - 07/2013
2	MonocrotalineIBA 05/2014 - 07/2013
2	pyridineIBA 01/2014 - 07/2013
2	Capsaicin (Zostrix)FDA Link 01/2014 - 01/2009
2	2- phenyl- N- (2- pyridinyl)imidazo(1,2- a)pyridin- 3- amineIBA 01/2014 - 01/2009
2	LASSBio-873IBA 07/2013 - 11/2009
2	Analgesics (Analgesic Drugs)IBA 07/2013 - 01/2009
2	Cholinergic Agents (Cholinergics)IBA 07/2013 - 11/2009
2	LASSBio-581IBA 05/2010 - 03/2008
2	Scopolamine (Hyoscine)FDA Link 02/2008 - 07/2005
1	diazonaphthalenedisulfonic acid (NDS)IBA 11/2020
1	1,3,4-thiadiazoleIBA 07/2020
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 01/2020
1	NitroimidazolesIBA 01/2020
1	CateninsIBA 12/2019
1	FlavonoidsIBA 12/2019
1	Chalcone (Benzalacetophenone)IBA 12/2019
1	duvelisibIBA 05/2019
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2019
1	Phosphotransferases (Kinase)IBA 01/2019
1	Protein Kinases (Protein Kinase)IBA 01/2018
1	CollagenIBA 01/2017
1	Silicon Dioxide (Silica)FDA LinkGeneric 01/2017
1	LASSBio-1422IBA 01/2017
1	barbituric acid (barbiturate)IBA 01/2017
1	N'- (4- (1H- pyrrolo(2,3- b)pyridin- 4- yl)benzylidene)- 2- naphthohydrazide hydrochlorideIBA 01/2016
1	Amphetamine (Amfetamine)FDA LinkGeneric 01/2016
1	Sildenafil Citrate (Viagra)FDA Link 05/2015
1	3,4- dimethoxyphenyl- N- methylbenzoylhydrazideIBA 05/2015
1	Adenosine (Adenocard)FDA LinkGeneric 05/2014
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2014
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 01/2014
1	Dihydrotachysterol (AT 10)IBA 01/2014
1	alpha Adrenergic ReceptorsIBA 08/2013
1	Cholinergic ReceptorsIBA 07/2013
1	N- (2- (4- (2- methoxyphenyl)- 1- piperazinyl)ethyl)- N- (2- pyridinyl)cyclohexanecarboxamideIBA 01/2013
1	5-HT1A Serotonin ReceptorIBA 01/2013
1	Haloperidol (Haldol)FDA LinkGeneric 01/2013
1	Hypnotics and Sedatives (Sedatives)IBA 01/2013
1	Clozapine (Clozaril)FDA LinkGeneric 01/2013
1	Biological ProductsIBA 11/2011
1	Antiviral Agents (Antivirals)IBA 11/2011
1	Antineoplastic Agents (Antineoplastics)IBA 11/2011
1	Anti-Infective Agents (Microbicides)IBA 11/2011
1	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 10/2011
1	Biological Warfare AgentsIBA 10/2011
1	Arachidonic Acid (Vitamin F)IBA 04/2011
1	N- (4- nitrobenzylidene)- 2- naphthohydrazideIBA 04/2011
1	LASSBio 294IBA 11/2010
1	N- (6- ((2- benzylidenehydrazinyl)carbonyl)- 1,3- benzodioxol- 5- yl)methanesulfonamideIBA 02/2009
1	p38 Mitogen-Activated Protein KinasesIBA 01/2009
1	SB 203580IBA 01/2009
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2009

Therapy/Procedure

7	Therapeutics 07/2020 - 05/2005
2	Oral Administration 01/2014 - 07/2013
2	Ligation 01/2014 - 07/2013
1	Drug Therapy (Chemotherapy) 10/2011